MSU researchers discover link between cholesterol and diabetic retinopathy
September 4, 2023 - MSUToday
Advancements that could lead to earlier diagnosis and treatment for diabetic retinopathy, a common complication that affects the eyes, have been identified by a multi-department research team from Michigan State and other universities.
Their findings were recently published in Diabetologia, the official journal of the European Association for the Study of Diabetes. Additional contributors are from the University of Alabama at Birmingham, Case Western Reserve University and Western University of Health Sciences. The study was funded by the National Eye Institute.
Researchers found that diabetes, age-related health conditions and other metabolic disorders can lead to a buildup of cholesterol in the retina. This tends to crystalize and contribute to the development of diabetic retinopathy.
George Abela, chief of the MSU Division of Cardiology, said that these cholesterol crystals are like the crystals found in atherosclerotic plaque that can form in arteries and cause heart attacks, a finding discovered in his lab at MSU. He helped the research team identify ways to scan retinas using modified tissue preparation for scanning electron microscopy. This also helps researchers analyze the composition of the crystals, which typically result when there is too much cholesterol in one place.